In many animal species, the early development of the embryo follows a stereotypic pattern of cell cleavage, lineage allocation and generation of tissue asymmetry leading to delineation of the body plan with three primary embryonic axes. The mammalian embryo has been regarded as an exception and primary body axes of the mouse embryo were thought to develop after implantation. However, recent findings have challenged this view. Asymmetry in the fertilised oocyte, as defined by the position of the second polar body (...) and the sperm entry point, can be correlated with the orientation of the animal–vegetal and the embryonic–abembryonic axes in the preimplantation blastocyst. Studies of the pattern of morphogenetic movement of cells and genetic activity in the peri‐implantation embryo suggest that the animal–vegetal axis of the blastocyst might presage the orientation of the anterior–posterior axis of the gastrula. This suggests that the asymmetry of the zygote that is established at fertilisation and early cleavage has a lasting impact on the delineation of body axes during embryogenesis. BioEssays 23:508–517, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

The focus of this study was to assess the mediating effect of green innovation, in the relationship between green human resources management (GHRM) and organizational competitiveness of manufacturing multinational enterprises (MNEs). The study further looked at the moderating effect of organizational learning in the relationship between GHRM on organizational competitiveness of manufacturing MNEs. The population comprises manufacturing MNEs in Ghana. Through purposive and simple random sampling techniques, 231 manufacturing MNEs were selected for the study. Data was analyzed using frequencies, percentages, (...) mean scores, and Structural Equation Modeling (SEM), using SPSS and SMART‐PLS (Partial Least Square) software. The study concludes that green innovation partially mediates the relationship between GHRM and organizational competitiveness. It was further concluded that organizational learning positively moderates the positive relationship between GHRM and organizational competitiveness. The study recommends that manufacturing MNEs should invest and improve the level of their organizational learning as it not only strengthens the effects of GHRM on organizational competitiveness, but it also directly improves competitiveness. Further, particular attention should also pay to green innovation, as it intervenes the relationship between GHRM and organizational competitiveness. (shrink)

The plane was going to crash, but it didn't. Johnny was going to bleed to death, but he didn't. Geach sees here a changing future. In this paper, I develop Geach's primary argument for the (almost universally rejected) thesis that the future is mutable (an argument from the nature of prevention), respond to the most serious objections such a view faces, and consider how Geach's view bears on traditional debates concerning divine foreknowledge and human freedom. As I hope to show, (...) Geach's view constitutes a radically new view on the logic of future contingents, and deserves the status of a theoretical contender in these debates. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:EXISTENTIAL PROPOSITIONS IN THE THOUGHT OF ST. THOMAS AQUINAS A REVALENT VIEW of St. Thomas Aquinas's position on the logic of propositions has been that according to him propositions of the :form, x is, hold a privileged place, that they are in a special sense " existential," and that such propositions straight.forwardly attribute the act of exi,stence to an individual or to a class of individuals.1 Some texts seem (...) to support such an interpretation. For example, in his commentary on Aristotle's Perihermeneias, Aquinas says: " To clarify this we must note that the verb 'is ' itself is sometimes predicated in an enunciation, as in ' Socrates is.' By this we intend to signify that Socrates really is." 2 This passage seems to treat the predicate " exists " or " is " as unproblematical, as though it had a straightforward meaning needing little clarification, at least in the context of a logical treatise. On the basis of such a text, one may be tempted to infer that for Aquinas " Socrates exists " has the same logical form as " Socrates sits," and that " Men exist " is of the same form as " Men are mortal.'' Peter Geach has shown, however, that Aquinas's doctrine here is not as simple as it may first appear. For Aquin,as some of the propositions which have the grammatical form of x is have 'a different logical form.3 Geach points out that for Aquinas the sentence, "Blindness exists," for example, actual1 E.g., Etienne Gilson, Being and Some Philosophers, 2nd ed. (Toronto: Pontifical Institute of Mediaeval Studies, 1952), 190-215. 2 Super Peri, Bk. II, lect. 2, # 212. Cf. Summa Contra Gentiles, Bk. II, ch. 37 at "FJ11J hoc..•." a Peter Geach, in P. T. Geach and G. E. M. Anscombe, Three Philosophers (New York: Cornell University, 1961), 88 ff; Peter Geach, "Form and Existence," in Aquinas: A Collection of Critical Essays, ed. A. Kenny (New York: Notre Dame U., 1969), pp. 41-47. 605 606 PATRICK LEE ly means, Something or other is blind. That is, blind is the real predicate rather than exists. Mo11eover, Geach argues, the logical peculiarity of this sentence is equally found in any sentence of the form, "an F exists." Such a proposition, " does not,attribute actuality (existence) to an F, but F-ness to something or other..." 4 And yet Geach will not apply rthis interpretation to all sentences of the form, " x is." He al'lgues that sentences in which " is " or " exists " is. joined to a logically pl'oper name are in a different category. Unlike in general propositions such as "an F exists," in such singular propositions, those using logically proper names, Geach,argues, actual existence is attributed to or predicated of an individual. "We have here a sense of 'is ' or 'exists ' that seems to me to be certainly a genuine predicate of individuals: the sense of ' exists ' in which one says that an individual came to exist, still exists, no longer exists, etc...."5 I believe that, while Geach's position is more accurate than the first interpretation, mentioned above, it is nevertheless still inaccurate on certain key points. While it is misleading to say that for Aquinas exists is never a genuine predicate; nevertheless, I will argue that it is his position that exists or existence is not a genuine predicate in any proposition which does not refer back to a previous proposition (or to what is known in or by previous propositional knowledge). Let us crull a proposition which refers to something known in a previous proposition a " second-order p11oposition," and one that does not thus refer a " first-order proposition." Then, I shall argue that for Aquinas exists is not a genuine predicate in any first-order proposition. Moreover, I believe that these points are crucial to understanding Aquinas's position on existence as well as his position on how knowledge is related,to reality, i.e., his realism. In this article I would like to examine Aquinas's thought on the logic of existential propositions and discuss its significance for epistemology. 4 Geach, " Form and Existence," Zoo. int., p. 45. 5 Ibid., p. 46. EXISTENTIAL PROPOSITIONS IN AQUINAS 607 In sections... (shrink)

Primary progressive multiple sclerosis (PPMS) shows a highly variable disease progression with poor prognosis and a characteristic accumulation of disabilities in patients. These hallmarks of PPMS make it difficult to diagnose and currently impossible to efficiently treat. This study aimed to identify plasma metabolite profiles that allow diagnosis of PPMS and its differentiation from the relapsing-remitting subtype (RRMS), primary neurodegenerative disease (Parkinson’s disease, PD), and healthy controls (HCs) and that significantly change during the disease course and could serve as surrogate (...) markers of multiple sclerosis (MS)-associated neurodegeneration over time. We applied untargeted high-resolution metabolomics to plasma samples to identify PPMS-specific signatures, validated our findings in independent sex- and age-matched PPMS and HC cohorts and built discriminatory models by partial least square discriminant analysis (PLS-DA). This signature was compared to sex- and age-matched RRMS patients, to patients with PD and HC. Finally, we investigated these metabolites in a longitudinal cohort of PPMS patients over a 24-month period. PLS-DA yielded predictive models for classification along with a set of 20 PPMS-specific informative metabolite markers. These metabolites suggest disease-specific alterations in glycerophospholipid and linoleic acid pathways. Notably, the glycerophospholipid LysoPC(20:0) significantly decreased during the observation period. These findings show potential for diagnosis and disease course monitoring, and might serve as biomarkers to assess treatment efficacy in future clinical trials for neuroprotective MS therapies. (shrink)

Streszczenie: Idea sacrum w lirycznej twórczości Dariusza Dekańskiego to konglomerat wielu składowych. Zarówno rzeczywistości konsystencjalnej, jak i tej sensytywnej – wyobrażonej, percypowanej na drodze synestezji. W prezentowanym artykule, pełniącym rolę asumptu do dalszych badań nad poetycką aktywnością autora Saudade, zwrócono szczególną uwagę na więź człowieka z Bogiem, kontakt z sacrum, przejawiającymi się w wewnętrznych przeżyciach podmiotu lirycznego, bezustannie szukającego swojego miejsca w świecie. Aby zbliżyć się do zrozumienia działań bohatera tej poezji wykorzystano przede wszystkim instrumentarium oferowane przez metodologie badań sacrum.

At present, there are almost 700 million rural population in China, and the farm and farmers in China are highly associated with the steadiness and development of the country and even the world. Farmers are the main subjects in rural development and play a vital role in the reception, management, and benefit distribution in rural tourism activities during the development of rural tourism. Farmers’ perception and participation intention in rural tourism development are directly related to the sustainable development of rural (...) tourism and the realization of rural revitalization goals. The decision-making process of participation in the rural tourism development fits the application conditions of the technology acceptance model. Therefore, in order to explore the influencing factors of farmers’ decision-making process in participating in the rural tourism, this study employs the technology acceptance model to predict and judge individual farmers’ willingness and behavior to participate in the rural tourism. The government trust and perceived risk in the real problem of low participation of farmers in the rural tourism development are considered. Then, an extended technology acceptance model was established by taking 409 farm households as research samples. The influence of government trust on farmers’ participation intention in the rural tourism was empirically analyzed based on the PLS-SEM model. The results show that farmers’ perceived usefulness and perceived ease of use in rural tourism affect their participation intention. Farmers’ judgments on whether governments can assume public responsibilities and achieve public interests through rural tourism development affects their trust in government, while the government trust can positively affect farmers’ participation intention via perceived usefulness and perceived ease of use. This indicates that government trust is an important antecedent variable influencing farmers’ participation in the rural tourism. The perceived risk affects farmers’ perceived usefulness and participation intention in the rural tourism, and plays a moderating role in the relationship between government trust and perceived usefulness. Finally, this study recommends to highlight the utility and convenience of rural tourism participation during the promotion of farmers’ participation in rural tourism development, enhance the ability of farmers to participate in rural tourism development, and choose multiple channels to increase government trust to reduce farmers’ risk concerns. (shrink)

This study argues that the notion of transparency requires reconsideration as an essence of ethical agency. It provides a brief explication of the concept of transparency, rooted in the principle of human dignity of Immanuel Kant, and suggests that it has been inadequately appreciated by media ethics scholars and instructors more focused on relatively simplistic applications of his categorical imperative. This study suggests that the concept's Kantian roots raise a radical challenge to conventional understandings of human interaction and, by extension, (...) what it means to exercise freedom. (shrink)

Griinbaum's own article sets forth his views on the ontology of the curvature of empty space, especially in the geometrodynamics of Clifford and Wheeler. ...

Cryptocurrency could redefine the interplay of Internet-connected world markets by eliminating constraints set by traditional local currencies and exchange rates. It has the potential to revolutionise digital markets through the use of duty-free trading. This study investigates the factors which influence the behavioural intention to use cryptocurrency based on the Technology Acceptance Model 3 (TAM 3) during the COVID-19 (SARS-COV-2) pandemic. Data were collected through a cross-sectional questionnaire from 357 Pakistani business-educated adults, including investors who had a rudimentary understanding of (...) the technology and financial instruments. Partial least square (PLS)-based structural equation modeling (SEM) was used to test the developed theoretical framework based on the Technology acceptance model 3. The PLS model has explained 72.1% of what constitutes the behavioural intention to use cryptocurrency. Surprisingly, risk was not a major consideration. This might be due to the fact that the majority of respondents thought working with cryptocurrency was hazardous. Willingness to handle cryptocurrency risk, on the other hand, might be a stumbling block to acceptance. The most essential aspect of a cryptocurrency's success was the perceived usefulness. Moreover, the moderating role of experience was not substantiated in this study. However, perceived usefulness was identified as a partial mediator of subjective norm and the perceived ease to use. This study contributed to the literature through the application of TAM 3 (an extension of the technology acceptance models) to investigate the fundamental qualities a cryptocurrency should have in order to influence investor's behavioural intention to use it. These findings provide revolutionary insights for the present and future market players for investment planning and for improved cryptocurrencies development. (shrink)

This paper develops and refines the suggestion that logical systems are conceptual artefacts that are the outcome of a design-process by exploring how a constructionist epistemology and meta-philosophy can be integrated within the philosophy of logic.

A bold exploration of the feminist revolution in Roman Catholic ethics, this book addresses controversial issues head on. This is the long-awaited first offering by the well-known feminist theologian, a professor of religion at Carleton College and a past president of the Catholic Theological Socity of America.

This paper reports on the findings of the third in a series of surveys of large U.S.-based and multinational corporations on their ethics statements. Focusing on four types – values statement, corporate credo, code of ethics and Internet privacy policy – we find growth in the use of these statements over the last decade. We discuss the external communication of these statements, including the avenues that are now used for promotion and their intended audiences. The paper concludes with a number (...) of research issues to be addressed. (shrink)

While the subjective experience of insight during problem solving is a common occurrence, an understanding of the processes leading to solution remains relatively uncertain. The goal of this study was to investigate the restructuring patterns underlying solution of a creative problem, and how providing cues to solution may alter the process. Results show that both providing cues to solution and analyzing problem solving performance on an aggregate level may result in restructuring patterns that appear incremental. Analysis of performance on an (...) individual level provides evidence for insight-like solution patterns. However, no evidence is found for a relationship between an individual’s restructuring pattern and their subjective experience of insight during problem solving. (shrink)

What part should description play in coming to judgment? Questions about genre have become more important in religious ethics as many seek to reform “thin” models of ethical arbitration by recourse to artistic, literary, and historical descriptions in their texts. In this book discussion, I explore what the consequences would be of pursuing this reform by turning to social anthropology—a discipline that relies on extensive empirical descriptions. I do this by considering the anthropology of ethics: a movement that seeks, for (...) the first time, to devote systematic and sustained attention the moral lives of ethnographic informants. I focus on the ways that authors within this field attempt to arrive at more realistic portraits of the different ways societies play out the familiar ethical themes of freedom, responsibility, suffering and agency. Their work challenges religious ethicists to consider what ethical conversation across these differences would look like, and thus to reconsider the relationship between description and judgment in their work. (shrink)

We have a certain fascination with the incredible untapped potential of our minds. Some studies once suggested that we use only 10% of the mind's capacity. Today that estimate has been revised to about 2%-3%. Imagine what more we could do with all of that as yet unrealized potential. What is standing in our way? How do we move into a more full realization of who we are? These are the questions that this book seeks to answer.

This is an important collection of essays dealing with the foundations of probability that will be of value to philosophers of science, mathematicians, statisticians, psychologists and educationalists. The collection falls into three parts. Part I comprises five essays on the axiomatic foundations of probability. Part II contains seven articles on probabilistic causality and quantum mechanics, with an emphasis on the existence of hidden variables. The third part consists of a single extended essay applying probabilistic theories of learning to practical questions (...) of education: it incorporates extensive data analysis. Patrick Suppes is one of the world's foremost philosophers in the area of probability, and has made many contributions to both the theoretical and practical side of education. The statistician Mario Zanotti is a long-time collaborator. (shrink)

This paper examines the contribution of the PhD dissertation of the American cytologist Michael F. Guyer (1874-1959) to the early establishment (in 1902-1903) of the parallel relationship between cytological chromosome behaviour in meiosis and Mendel's laws. Guyer's suggestions were among the first, which attempted to relate the variation observed in the offspring in hybridisation studies by a coherent cytological chromosome mechanism to meiosis before the rediscovery of Mendel's principles. This suggested for the first time that the chromosome mechanism involved a (...) conjugation of maternal and paternal chromosomes during the synapsis followed by a segregation of parental chromosomes in the final germ cells and a random union of the final germ cells in the fertilization. It shows that this early suggestion was similar to William Austin Cannon's later chromosome proposal attempting to explain Mendel's principles and had some influence on Walter Sutton's cytological suggestion explaining correctly the behaviour of Mendel's particle by 1903. (shrink)

By resituating Alexander von Humboldt in the “working world” of mining, this essay offers a case study of the way in which industry has shaped practice and theory in the history of science. While Humboldt’s experience as a miner in Saxony and Prussia provided him a venue in which to study fossilized vegetation, revealing a fundamental link between the migrations of plants and of peoples, industrial concerns about miners’ safety inspired a study of the interplay between plants and people that (...) shaped his later articulation of the verticality of plant distribution. Moreover, the cartographic methods Humboldt employed during his American journey depended as much on drawing practices indebted to mining as they did on patterns of vertical mobility above and below the surface of the earth. These arguments ultimately encourage a departure from “Humboldtian Science,” a term that has veiled an originally Prusso-Saxon science beneath a set of Anglo-American connotations. (shrink)

Cet article présente, contre le physicalisme, un argument métaphysique fondé sur la distinction entre les propriétés intrinsèques et extrinsèques. Il soutient que le physique, comme le physicalisme doit le comprendre, comprend uniquement des propriétés extrinsèques, tandis que la conscience implique au moins certaines propriétés intrinsèques. Il conclut que la conscience a des propriétés non-physiques et que le physicalisme est faux. L’article défend ensuite ses prémisses contre la pensée physicaliste actuelle. Autant que possible, il offre des arguments métaphysiques portant sur les (...) propriétés physiques et conscientes plutôt que des arguments épistémologiques portant sur nos concepts physiques et phénoménaux. (shrink)

Auch in der katholischen Kirche nimmt ein Lagerdenken zu: eine "moderne", "linke" Seite gegen eine "konservative", "traditionalistische". Becker zeichnet nach, wie sich die Kontroverse um die zugrunde liegenden ungleichen Wahrheitsverstandnisse durch die europaische Philosophiegeschichte zieht. Er nimmt so der innerkirchlichen Polarisierung die Scharfe und zeigt, wie das vorherrschende relativistische Wahrheitsverstandnis mit dem Wahrheitsanspruch der christlichen Botschaft vereint werden kann.